1109 Experiment St. - Melton Building - Griffin, GA 30223 USA - PH (770) 228-7284 - FAX (770) 229-3216
Dr. Jia-Sheng Wang
Professor and Department Head

Dept. Environmental Health Science
150 Green Street, Room 206-A
University of Georgia
Athens, GA 30602-2102
Office Phone: (706) 542-2454
E-Mail: jswang@uga.edu

Overview of Research Program
Mechanistic studies for environmental toxicants
Molecular epidemiology of human acute and chronic diseases with environmental origins
Cancer chemoprevention
Food and nutritional toxicology
Natural products
 
Recent Publications (2003 - present)
 

Tang, L., Tang, M., Xu, L., Luo, H., Huang, T., Yu, J., Zhang, L., Cox, SB., Gao, W.-M and Wang, J.-S. (2008). Modulation of Aflatoxin Biomarkers in Human Blood and Urine by Green Tea Polyphenols Intervention. Carcinogenesis 29(2):411-417.

Wang, J.-S., Luo, H., Wang, P. Tang, L., Yu, J., Huang, T., Cox, S. B., Gao, W. (2008). Validation of Green Tea Polyphenol Biomarkers in a Phase II Human Intervention Trial. Food Chem Toxicol. 46:232-240.

Shen, C.-L., Wang P., Guerrier, J., Yeh, J. K. and Wang, J.-S (2008) Protective effect of green tea polyphenols on bone loss in middle-aged female rats. Osteopros Int. 19(7):979-990.

Afriyie-Gyawu, E., Ankrah, N.-A., Huebner, H. J., Ofosuhene, M., Kumi, J., Johnson, N. M., Tang, L., Xu, L., Jolly, P.E., Ellis, W. O., Ofori-Adjei, D., Williams, J. H., Wang, J.-S. & Phillips, T. D. (2008). NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis. I. Study design and clinical outcomes. Food Additives & Contam, 25(1):76-87.

Phillips, T. D., Afriyie-Gyawu, E., Williams, J., Huebner, H., N-A. Ankrah, N-A., Ofori-Adjei, D., Jolly, P., Johnson, N., Taylor , J., Marroquin-Cardona, A., Xu, L., Tang, L., Wang, J.-S. (2008). Reducing Human Exposure to Aflatoxin through Use of Clay. Food Additives & Contam, 25(2):134-145.

Billam, M., Mukhi, S., Tang, L., Gao, W., and Wang, J.-S. (2008) Toxic response indicators of microcystin-LR in F344 rats following a single dose treatment. Toxcon 51(6):1068-1080.

Wang, P., Afriyie-Gyawu, E., Tang, Y., Johnson,N. M., Xu, L., Tang, L., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Ellis, W., Jolly, P. E., Williams, J. H., Wang, J.-S., Phillips, T. D. (2008). NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine, Food Additives & Contam, 25 (5):622-634.

Cai, Q., Tang, L. and Wang, J.-S. (2007). Validation of fumonisin biomarkers in F344 rats. Toxicol Appl. Pharmacol. 225:28-39.

Tang, L., Guan H., Ding, X. and Wang, J.-S. (2007). Modulation of aflatoxin toxicity and biomarkers by lycopene in F-344 rats. Toxicol Appl. Pharmacol. 219:10-17.

Sun, G., Wang, S., Hu, X., Su, J., Huang, T., Yu, J., Tang, L., Gao, W. and Wang, J.-S. (2007). Fumonisin B1 contamination of home-grown corn in high-risk areas of esophageal and liver cancers in China . Food Additives & Contam. 24(2):181-185.

Dash, B., Afriyie-Gyawu, E, Huebner, H. J., Porter, W., Wang, J.-S, Jolly, P. E., Phillips, T. D. (2007). Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. J Toxicol. Environ. Health Part A 70:58-66.

Jolly, P. E., Jiang, Y., Ellis, W. O., Awuah, R. T., Appawu, J., Nnedu, O., Stiles, J. K., Wang, J-S., Adjei, O., Jolly, C. M., Williams, J. H. (2007). Association between aflatoxin exposure and health characteristics, liver function, hepatitis and malaria infections in Ghanaians. J. Nutri & Environ. Med. 16 (3):1-16.

Luo, H., Cox, SB., Gao, W.-M., Yu, J., Tang, L. and Wang, J.-S. (2006). Metabolic Profiling in Validation of Plasma Biomarkers for Green Tea Polyphenols. Metabolomics, 2(4):235-241.

Wang, Z., Tang, L., Sun, G., Tang, Y., Xie, Y., Wang, S., Hu, X., Gao, W., Cox, S. B. and Wang J.-S. (2006). Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian , China . BMC Cancer 2006, 6:287 doi:10.1186/1471-2407-6-287

Pan XP, Zhang BH, Tian K, Jones LE, Liu J, Anderson TA, Wang J.-S., Cobb GP (2006). Liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). Rapid Commun. Mass Spectrom 20:2222-2226.

Egner , PA , Groopman, JD., Wang, J.-S., Kensler, TW., and Friesen , MD (2006). Quantification of aflatoxin B1-N7-guanine in human urine by HPLC-Isotope-Dilution Tandem Mass Spectrometry. Chem. Res. Toxicol. 18:1191-1195.

Wang, S-L., He, X-Y., Shen, J., Wang, J.-S. and Hong, J-Y. (2006) The Missense Genetic Polymorphisms of Human CYP2A13: Functional Significance in Carcinogen Activation and Identification of A Null Allelic Variant . Toxicol. Sci. 94(1):38-45.

Luo, H., Tang, L., Billam, M., Tang, M., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., Zhang, L., and Wang, J.-S. (2006). Phase IIa chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: II. Modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis. 27:262-268.

Billam, M., Tang, L., Cai, Q., Mukhi, S., Guan, H., Wang, P., Wang, Z. and Wang, J.-S. (2006). Seasonal Variations in the Concentration of Microcystin-LR Contamination in Lakes of West Texas . Environ. Toxicol. Chem. 25(2):356-366.

McKean, C., Tang, L., Billam, M., Tang, M., Theodorakis, C. W., Kendall, R. J. and Wang, J.-S (2006). Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortilized human cell lines. J. Appl Toxicol. 26(2):139-147.

McKean, C., Tang, L., Tang, M., Billam, M., Wang, Z.,Theodorakis, C. W., Kendall, R. J. and Wang, J.-S (2006). Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cell lines. Food Chem. Toxicol. 44(6):868-876.

Liu, F., Wang, J.-S., and Theodorakis, C.W. (2006). Genotoxicity and oxidative stress caused by sodium arsenate and sodium perchlorate in zebrafish Danio rerio. Environ Sci. Technol. 40:3429-3436.

Dash, B., Afriyie-Gyawu, E, Huebner, H. J., Porter, W., Wang, J.-S, Jolly, P. E., Phillips, T. D. (2006). Noninvasive identification of inter-individual variation in xenobiotic metabolizing enzymes: implications for cancer epidemiology and biomarker studies. J Toxicol. Environ. Health A 69(13):1203-1216.

He, X-Y., Tang, L., Wang, S-L., Cai, Q., Wang, J.-S. and Hong, J-Y. (2006). Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. Int. J. Cancer, 118(11):2665-2671.

Jolly, P., Jiang, Y., Ellis, W., Awuah, R., Nnedu, O., Phillips, T., Wang, J.-S., Tang, L., Afriyie-Gyawu, E., Person, S., Williams, T. and Jolly, C. (2006). Determinants of aflatoxin levels in Ghanaians: sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. Int. J. Hyg. Environ.-Health 209:345-358.

Xu, H., Sun, G., Wang, S., Hu, X., and Wang, J.-S (2006) Determination of aflatoxins and fumonisins in the corn and peanut on sale. J Environ Occup Med. 23(3):217-219.

Xiong, L., Tang, M., and Wang, J.-S. (2006). Combinative Cytotoxicity of aflatoxin B1 and Microcystin-LR in HepG2 cells. J. Chinese Public Health 22 (5): 548-550.

Sun, G.-J, Wang, S.-K., and Wang, J.-S. (2006). The combined toxicity of two kinds of mycotoxin in Sprague-Dawley rats. Chin J Prev Med 40(5):319-323.

Tang, L., Jin, T., Zheng, X. and Wang, J.-S. (2005). Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J. Nutr. 135(2): 287-290.

Afriyie-Gyawu, E., Mackie, J., Dash, B., Wiles, M., Taylor , J., Huebner, H., Tang, L., Guan, H., Wang, J.-S. and Phillips, T. D. (2005). Long-term toxicological evaluation of NovaSil clay in the diet of Sprague-Dawley rats. Food Add & Contam. 22 (3): 259-269

Wang, J.-S., Luo, H., Billam, M., Wang, Z., Guan, H., Tang, L., Goldston, T., Afriyie-Gyawu, E., Lovett, C., Griswold, J., Brattin, B., Huebner, H. J. and Phillips, T. D. (2005). Short-term safety evaluation of NovaSil in humans. Food Add. & Contam. 22 (3): 270-279.

Jiang, Y., Jolly, P. E., Ellis, W. O., Wang, J.-S., Phillips, T., Williams, J. H. (2005). Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. International Immunol. 17(6):807-814.

Xie, Y., Sun, G., Xiong, C., Wang, S., Wang, H. and Wang, J.-S. (2005). Determination of T-2 toxin in staple food from KBD families in Xinhai County , Qinghai Province. Chinese J. Fd Hyg., 17:157-159.

Wang, J.-S and Tang, L. (2004). Aflatoxin exposure and human liver cancer. J. of Toxicol, 23:249-271.

Tang, L., Tang, M., He, X., Busby, W. F., and Wang, J.-S. (2004). Tumorigenicity of airborne complex mixtures. J. Toxicol. Pharmacol. 18:134-140.

Sun, G., Xiong, C., Zhang, Y., Wang, S., Xie, Y. Wang, H., Shi, N. and Wang, J.-S. (2004). Comparison of contents of trace elements in wheat samples from the control and endemic Kashin-Beck disease areas. Trace Element & Health, 21:23-26.

Huang, T., Yu, J., Tang, L., Luo, H., Billam, M., Wei, Z., Liang, Y., Li, Y., Wang, K., Shi, J., Cui, Y., Zhang, Z-Q., Zhang, L., Sun, S., Martin, C. and Wang, J.-S. (2004). Phase IIa chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: I. Design, clinical outcome, and baseline biomarker data. J. Int. Cancer Prev. 1:269-280.

Wu, Y., Lu, P., Wang, J.-S., Wang, J., Wan, S., Kensler T. W., Groopman, J. D. and Qian, G.-S (2003). Correlation between the genetic polymorphism of EPHX and susceptibility to hepatocellular carcinoma, Tumor, 23:287-289.