1109 Experiment St. - Melton Building - Griffin, GA 30223 USA - PH (770) 228-7284 - FAX (770) 229-3216
Dr. Kenneth Voss
Research Pharmacologist

U. S. Dept. of Agriculture
950 College Station Rd.
Russell Research Center
Athens, GA 30605-2720
Office Phone: (706) 546-3315
Fax: (706) 546-3116

E-Mail: Ken.Voss@ars.usda.gov

Overview of Research Program
The fate of fumonisins in corn through processing steps in the manufacture of corn chips
 
Recent Publications (2002 - present)
 

Seiferlein, M., H.U. Humpf, K.A. Voss, M.C. Sullards, J.C. Allegood, E. Wang, and A.H. Merrill. 2007. Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.  Molecul. Nutr. Food Res. 51:1120-1130.

Voss, K.A., G.W. Smith, and W.M. Haschek. 2007. Fumonisins: Toxicokinetics, mechanism of action and toxicity.  Anim. Feed Sci. Technol. 137:299-325.

Riley, R.T. and K.A. Voss. 2006. Differential sensitivity of rat kidney and liver to fumonisin toxicity: Organ-specific differences in toxin accumulation and sphingoid base metabolism.  Toxicol. Sci. 92:335-345.

Voss, K.A., J. Liu, S.P. Anderson, C. Dunn, J.D. Miller, J.R. Owen, R.T. Riley, C.W. Bacon, and J.C. Corton. 2006. Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor a.  Toxicol. Sci. 89:108-119.

Voss, K.A., W.P. Norred, F.I. Meredith, R.T. Riley, and D.S. Saunders. 2006. Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips.  J. Toxicol. Environ. Health (Part A.) 69:1387-1397.

Voss, K.A., R. Riley, C. Dunn, and J.C. Corton. 2006. The role of tumor necrosis factor a and the peroxisome proliferator-activated receptor a in modulating the effects of fumonisin in mouse liver.  Toxicol. 222:165-174.

Waes, J.G., L. Starr, J. Maddox, F. Aleman, K.A. Voss, J. Wilberding, and R.T. Riley. 2005. Maternal fumonisin exposure and risk for neural tube defects: Mechanisms in an in vivo mouse model.  Birth Defects Res. Part. A. Clin. Molecul. Teratology 73:487-497.

Xiao, S., S.P. Anderson, C. Swanson, R. Bahnemann, K.A. Voss, A.J. Stauber, and J.C. Corton. 2006. Activation of peroxisome proliferator-activated receptor α (PPAR α) enhances apoptosis in the mouse liver.  Toxicol. Sci. 92:368-377.

Gelineau-van Waes, J., L. Starr, J. Maddox, F. Aleman, K. A. Voss, J. Wilberding, R. T. Riley. 2005. Maternal fumonisin exposure and risk for neural tube defects: Mechanisms in an in vivo mouse model.  Birth Defects Res. A. Clin. Mol. Teratol. 73:487-497.

Stauber, A. J., H. Brown-Borg, J. Liu, M. P. Waalkes, A. Laughter, R. A. Staben, J. C. Coley, C. Swanson, K. A. Voss, J. J. Kopchick, and J. C. Corton. 2005. Constitutive expression of peroxisome proliferators-activated receptor alpha-regulated genes in dwarf mice.  Mol. Pharmacol. 67:681-694.

Voss, K. A., R. T. Riley, and J. B. Gelineau-van-Waes. 2005. Trends in fumonisin research: Recent studies on the developmental effects of fumonisins and Fusarium verticillioides.  Mycotoxins 55:91-100.

Corton, J. C., U. Apte, S. P. Anderson, P. Limaye, L. Yoon, J. Latendresse, C. Dunn, J. L. Everitt, K. A. Voss, C. Swanson, C. Kimbrough, J. S. Wong, S. S. Gill, R. A. Chandraratna, M. K. Kwak, T. W. Kensler, T. M. Stulnig, K. R. Steffensen, J. A. Gustafsson, and H. M. Mehendale. 2004. Mimetics of calorie restriction include agonists of lipid-activated nuclear receptors.  J. Biol. Chem. 279:46204-46212.

Humpf, H.-U. and K. A. Voss. 2004. Effects of thermal food processing on the chemical structure and toxicity of fumonisin mycotoxins.  Molecul. Nutr. Food Res. 48:255-269.

Marasas, W. F. O., R. T. Riley, K. A. Hendricks, V. L. Stevens, T. W. Sadler, J. Gelineau-van Waes, S. A. Missmer, J. Cabrera, O. Torres, W. C. A. Gelderblom, J. Allegood, C. Martinez, J. Maddox, J. D. Miller, L. Starr, M. C. Sullards, A.V. Roman, K. A. Voss, E. Wang, and A. H. Merrill, Jr. 2004. Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: A potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize.  J. Nutr. 134:711-716.

Sharma, R. P., Q. He, V. J. Johnson, and K. A. Voss. 2003. Increased expression of CD95-ligand and other apoptotic signaling factors by fumonisin B1, a hepatotoxic mycotoxin, in livers of mice lacking tumor necrosis alpha.  Cytokine 24:226-236.

Voss, K. A., F. I. Meredith, and C. W. Bacon. 2003. Effect of baking and frying on the in vivo toxicity to rats of cornmeal containing fumonisins.  J. Agric. Food Chem. 51:5546-5551.

Dresden Osborne, C., G. Pittman Noblet, E. N. Enongene, C. W. Bacon, R. T. Riley, and K.A. Voss. 2002. Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticilliodes (=F. moniliforme) culture material containing fumonisins. Food Chem. Toxicol. 40:1789-1798.

Enongene, E. N., R. P. Sharma, N. Bhandari, J. D. Miller, F. I. Meredith, K. A. Voss, and R. T. Riley. 2002. Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. Toxicol. Sci. 67:173-181.

Sharma, R. P., Q. He, F. I. Meredith, R. T. Riley, and K. A. Voss. 2002. Paradoxical role of tumor necrosis factor alpha in fumonisin-induced hepatotoxicity in mice. Toxicol. 180:221-232.

Voss, K. A., P. C. Howard, R. T. Riley, T. J. Bucci, and R. J. Lorentzen. 2002. Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (=F. verticillioides). Cancer Detect. Prev. 26:1-9.