1109 Experiment St. - Melton Building - Griffin, GA 30223 USA - PH (770) 228-7284 - FAX (770) 229-3216
Dr. Michael Doyle
Regents Professor of Food Microbiology
Director, Center for Food Safety

Center for Food Safety
Dept. Food Science & Technology
University of Georgia
Griffin, GA 30223-1797
Office Phone: (770) 228-7284
E-Mail: mdoyle@uga.edu
Overview of Research Program
Dr. Doyle's research is in the area of food microbiology and focuses on bacterial foodborne pathogens.
Pathogens under study include Escherichia coli O157:H7 and other serotypes of enterohemorrhagic E. coli, Salmonella spp., Campylobacter jejuni, Listeria monocytogenes, Staphylococcus aureus, and Clostridium botulinum.
Development of probiotic/competitive exclusion bacteria to reduce/eliminate carriage of E. coli O157:H7 by cattle and Campylobacter jejuni by poultry.
Development of treatments using approved chemicals to kill foodborne pathogens on produce, meat and poultry.
Development of methods to isolate Helicobacter pylori from foods.
Studies on the infectious dose of Listeria monocytogenes
Studies on the ecology of Salmonella typhimurium DT104
 
Patents
Doyle, M. P., T. Zhao, B. G. Harmon, and C. A. Brown. November 5, 2003. Control of enterohemorrhagic E. coli O157:H7 in cattle by probiotic bacteria. China Patent No. ZL 98808111.3.

Doyle, M. P., T. Zhao, B. G. Harmon, and C. A. Brown. January 10, 2002. Control of enterohemorrhagic E. coli O157:H7 in cattle by probiotic bacteria. New Zealand Patent No. 502420.

Doyle, M. P., T. Zhao, B. G. Harmon, and C. A. Brown. October 12, 1999. Control of enterohemorrhagic E. coli O157:H7 in cattle by probiotic bacteria. U.S.A. Patent #5,965,128.
Recent Publications (2003 - present)
 

Danyluk, M.D., T. Zhao, and M.P. Doyle. 2007. Competitive inhibition bacteria of bovine origin against Salmonella serovars.  J. Food Prot. 70:1804-1810.

Erickson, M.C. and M.P. Doyle. 2007. Food as a vehicle for transmission of Shiga toxin-producing Escherichia coli.  J. Food Prot. 70:2426-2449.

Ma., L., J.L. Kornacki, G.D. Zhang, C.M. Lin, and M.P. Doyle. 2007. Development of thermal surrogate microorganisms in ground beef for in-plant critical control point validation studies.  J. Food Prot. 70:952-957.

Ma, L., G. Zhang, J. Sobel, and M.P. Doyle. 2007. Evaluation of the effect of acetylsalicylic acid on Clostridium botulinum growth and toxin production.  J. Food Prot. 70:2860-2863.

Shepherd, M.W., P.F. Liang, X.P. Jiang, M.P. Doyle, and M.C. Erickson. 2007. Fate of Escherichia coli O157:H7 during on-farm dairy manure-based composting.  J. Food Prot. 70:2708-2716.

Zhang, G.D., L. Ma, and M.P. Doyle. 2007. Potential competitive exclusion bacteria from poultry inhibitory to Campylobacter jejuni and Salmonella.  J. Food Prot. 70:867-873.

Zhang, G.D., L. Ma, and M.P. Doyle. 2007. Salmonellae reduction in poultry by competitive exclusion bacteria Lactobacillus salivarius and Streptococcus cristatus.  J. Food Prot. 70:874-878.

Zhang, G., L. Ma, O.A. Oyarzabal, and M.P. Doyle. 2007. Aerosol studies with Listeria innocua and Listeria monocytogenes.  J. Food Prot. 70:1857-1865.

Zhang, G.D., L. Ma, N. Patel , B. Swaminathan, S. Wedel, and M.P. Doyle. 2007. Isolation of Salmonella typhimurium from outbreak-associated cake mix.  J. Food Prot. 70:997-1001.

Doyle, M.P. 2006. Dealing with antimicrobial resistance.  Food Technol. 60(8):22-29.

Doyle, M.P. and M.C. Erickson. 2006. Reducing the carriage of foodborne pathogens in livestock and poultry. Poultry Sci. 85:960-973.

Doyle, M.P. and M.C. Erickson. 2006. Emerging microbiological food safety issues related to meat. Meat Sci. 74:98-112.

Doyle, M.P. and M.C. Erickson. 2006. Closing the door on the fecal coliform assay.  Microbe 1(4):162-163.

Council for Agricultural Science and Technology (CAST) Task Force. 2006. Issue paper: Using risk analysis to inform microbial food safety decisions.  CAST Issue Paper 31:1-20.

Jiang, X.P., H. Yang, B. Dettman, and M.P. Doyle. 2006. Analysis of fecal microbial flora for antibiotic resistance in ceftiofur-treated calves.  Foodborne Pathogens Dis. 3:355-365.

Lin, C.M., K. Takeuchi, L. Zhang, C.B. Dohm, J. D. Meyer, P.A. Hall, and M.P. Doyle. 2006. Cross-contamination between processing equipment and deli meats by Listeria monocytogenes.  J. Food Prot. 69:71-79.

Lin, C.M., L. Zhang, M.P. Doyle, and B. Swaminathan. 2006. Comparison of media and sampling locations for isolation of Listeria monocytogenes in queso fresco cheese.  J. Food Prot. 69:2151-2156.

Mao,Y., M.P. Doyle, and J. Chen. 2006. Role of colonic acid exopolysaccharide in the survival of enterohaemorrhagic Escherichia coli O157:H7 in simulated gastrointestinal fluids. Lett. Appl. Microbiol. 42:642-647.

Mytle, N., G.L. Anderson, M.P. Doyle, and M.A. Smith. 2006. Antimicrobial activity of clove (Syzgium aromaticum) oil in inhibiting Listeria monocytogenes on chicken frankfurters.  Food Control 17:102-107.

Mytle, N., G.L. Anderson, S. Lambert, M.P. Doyle, and M.A. Smith. 2006. Effect of fat content on infection by Listeria monocytogenes in a mouse model.  J. Food Prot. 69:660-665.

Takeuchi, K., N. Mytle, S. Lambert, M. Coleman, M.P. Doyle, and M.A. Smith. 2006. Comparison of Listeria monocytogenes virulence in a mouse model.  J. Food Prot. 69:842-846.

Zhao, T. and M.P. Doyle. 2006. Reduction of Campylobacter jejuni on chicken wings by chemical treatments.  J. Food Prot. 69:762-767.

Zhao, T., T.C. Podtburg, P. Zhao, B.E. Schmidt, D.A. Baker, B. Cords, and M.P. Doyle. 2006. Control of Listeria spp. by competitive-exclusion bacteria in floor drains of a poultry processing plant.  Appl. Environ. Microbiol. 72:3314-3320.

Zhao, T., P. Zhao, J.W. West, J.K. Bernard, H.G. Cross, and M.P. Doyle. 2006. Inactivation of enterohemorrhagic E. coli in drinking water for cattle contaminated with rumen content or feces.  Appl. Environ. Microbiol. 72:3268-3273.

Batz, M. B., M. P. Doyle, J. G. Morris, J. Painter, R. Singh, R. B. Tauxe, M. R. Taylor, and D. M. A. Lo Fo Wong. 2005. Attributing illness to food.  Emerg. Infect. Dis. 111:993-999.

ILSI Research Foundation Risk Science Institute Expert Panel on Listeria monocytogenes in foods. 2005. Achieving continuous improvement in reductions in foodborne listeriosis – A risk-based approach.  J. Food Prot. 68:1932-1994.

Islam, M., M. P. Doyle, S. C. Phatak, P. Millner, and X. Jiang. 2005. Survival of Escherichia coli O157:H7 in soil and on carrots and onions grown in fields treated with contaminated manure composts or irrigation water.  Food Microbiol. 22:63-70.

Mytle, N., G. L. Anderson, M. P. Doyle, and M. A. Smith. 2005. Antimicrobial activity of clove (Syzgium aromaticum) oil in inhibiting Listeria monocytogenes on chicken frankfurters.  Food Control 17:102-107.

Strachan, N. J. C., M. P. Doyle, F. Kasuga, O. Rotariu, and I. D. Ogden. 2005. Dose response modeling of Escherichia coli O157 incorporating data from foodborne and environmental outbreaks.  Int. J. Food Microbiol. 103:35-48.

Busta, F. F., M. P. Doyle, R. S. Flowers, R. G. Labbe, J. Lovett, J. M. Madden, J. C. McEntire, R. L. Newsome, M. D. Pierson, and N. R. Reddy. 2004. Bacteria associated with foodborne diseases.  Food Technol. 58(7):95-103.

Chiou, R. Y.-Y., R. D. Phillips, P. Zhao, M. P. Doyle, and L. R. Beuchat.  2004.  Ethanol-mediated variations in fatty acid composition and protein profiles of two genotypically different strains of Escherichia coli O157:H7.  Appl. Environ. Microbiol.  70:2204-2210.

Doyle, M. P., G. R. Acuff, D. Bernard, B. Cords, J. Cullor, J. Hollingsworth, K. P. Penner, S. Seward, W. A. Sperber, and B. Tompkin. 2004. Intervention strategies for the safety of foods of animal origin.  Council for Agricultural Science and Technology (CAST) Issue Paper No. 25, pp. 1-24.

Erickson, M. C., M. Islam, C. Sheppard, J. Liao, and M. P. Doyle. 2004. Reduction of Escherichia coli O157:H7 and Salmonella enterica serovar Enteritidis in chicken manure by larvae of the black soldier fly.  J. Food Prot. 67:685-690.

Islam, M., M. P. Doyle, S. C. Phatak, P. Millner, and X. P. Jiang. 2004. Persistence of enterohemorrhagic Escherichia coli O157:H7 in soil and on leaf lettuce and parsley grown in fields treated with contaminated manure composts or irrigation water.  J. Food Prot. 67:1365-1370.

Islam, M., J. Morgan, M. P. Doyle, and X. P. Jiang. 2004. Fate of Escherichia coli O157:H7 in manure compost-amended soil and on carrots and onions grown in an environmentally controlled growth chamber.  J. Food Prot. 67:574-578.

Islam, M., J. Morgan, M. P. Doyle, S. C. Phatak, P. Millner, and X. P. Jiang. 2004. Fate of Salmonella enterica serovar Typhimurium on carrots and radishes grown in fields treated with contaminated manure composts or irrigation water.  Appl. Environ. Microbiol. 70:2497-2502.

Islam, M., J. Morgan, M. P. Doyle, S. C. Phatak, P. Millner, and X. P. Jiang. 2004. Persistence of Salmonella enterica serovar Typhimurium on lettuce and parsley and in soils on which they were grown in fields treated with contaminated manure composts or irrigation water.  Foodborne Pathogens Dis. 1:27-35.

Jiang, X. P., M. Islam, J. Morgan, and M. P. Doyle. 2004. Fate of Listeria monocytogenes in bovine manure-amended soil.  J. Food Prot. 67:1676-1681.

Zhao, T., M. P. Doyle, M. C. Kemp, R. S. Howell, and P. Zhao. 2004. Influence of freezing and freezing plus acidic calcium sulfate and lactic acid addition on thermal inactivation of Escherichia coli O157:H7 in ground beef.  J. Food Prot. 67:1760-1764.

Zhao, T., M. P. Doyle, and P. Zhao. 2004. Control of Listeria monocytogenes in a biofilm by competitive-exclusion microorganisms.  Appl. Environ. Microbiol. 70:3996-4003.

Jiang, X., J. Morgan, and M. P. Doyle. 2003. Fate of Escherichia coli O157:H7 during composting of bovine manure in a laboratory-scale bioreactor.  J. Food Prot. 66:25-30.

Jiang, X., J. Morgan, and M. P. Doyle. 2003. Thermal inactivation of Escherichia coli O157:H7 in cow manure compost.  J. Food Prot. 66:1771-1777.

Lin, C.-M., F. M. Wu, H.-K. Kim, M. P. Doyle, B. S. Michaels, and L. K. Williams. 2003. A comparison of handwashing techniques to remove Escherichia coli and caliciviruses under natural or artificial fingernails.  J. Food Prot. 66:2296-2301.

Michaels, B., V. Gangor, C.-M. Lin, and M. P. Doyle. 2003. Use limitations of alcoholic instant hand sanitizer as part of a food service hand hygiene program.  Food Serv. Tech. 3:71-80.

Smith, M. A., K. Takeuchi, R. E. Brackett, H. M. McClure, R. B. Raybourne, K. M. Williams, U. S. Babu,
G. O. Ware, J. R. Broderson, and M. P. Doyle. 2003. A nonhuman primate model for Listeria monocytogenes-induced stillbirths.  Infect. Immun. 71:1574-1579.

Takeuchi, K., M. A. Smith, and M. P. Doyle. 2003. Pathogenicity of food and clinical Listeria monocytogenes isolates in a mouse bioassay.  J. Food Prot. 66:2362-2366.

Tkalcic, S., T. Zhao, B. G. Harmon, M. P. Doyle, C. A. Brown, and P. Zhao. 2003. Fecal shedding of enterohemorrhagic Escherichia coli in weaned calves following treatment with probiotic Escherichia coli.  J. Food Prot. 66:1184-1189.

Zhao, T., G. O. I. Ezeike, M. P. Doyle, Y.-C. Hung, and R. S. Howell. 2003. Reduction of Campylobacter jejuni on poultry by low-temperature treatment.  J. Food Prot. 66:652-655.

Zhao, T., S. Tkalcic, M. P. Doyle, B. G. Harmon, C. A. Brown, and P. Zhao. 2003. Pathogenicity of enterohemorrhagic Escherichia coli in neonatal calves and evaluation of fecal shedding by treatment with probiotic Escherichia coli.  J. Food Prot. 66:924-930.